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XX : Plusieurs codons pour le même AA. Ex : GGG remplacé par GGA tous les deux codent pour la glycine. Remplacement d’une base par une autre mais le codon code toujours pour le même AA. Dans certains cas le fait de changer d'acide nucléique influe sur l'épissage. Certaines zones ne sont pas reconnues et on peut avoir des anomalies d'épissage et d'expression des gènes. Toutes les mutations synonymes ne sont pas sans conséquences.

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