Which one of the following is correct? A) All enzymes are highly specific for the reactions they catalyze. B) Prosthetic groups are loosely associated with the polypeptide chain of an enzyme. C) Activation of zymogens, such as proelastase, requires an oxidation-reduction reaction at a particular amino acid side chain. D) If an enzyme-catalyzed reaction requires a group with a low pK to be deprotonated and a group with a higher pK to be protonated, the pH vs. velocity curve will have a peak in the middle. E) The proximity effect, a result of bringing substrates close to their catalytic groups in the active site, can result in a rate enhancement on the order of 10^6 .

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