What explains why primaquine-induced hemolytic anemia in individuals with a G6PD deficiency range from mild to severe even when given the same dose of primaquine?Because there are a large number of distinct mutations in the G6PD gene that affect enzyme activity to different degrees.Because males and females have different G6PD gene variants and the studies did not take into account gender differences.Because it is difficult to measure the dose of primaquine accurately enough to ensure all patients received the same amount of drug.Because mild hemolytic anemia is hard to measure, whereas severe hemolytic anemia is easy to measure based on red blood cells.Because there is only one mutation in the G6PD gene that causes hemolytic anemia, but there are different manufacturers of primaquine.

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