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évolution agressive et rapidement péjorative en l'absence de traitement, caractérisées par un blocage de maturation à un stade immature et une prolifération accrue à l'origine d'un excès de blastes. Altération de l'hématopoïèse en raison de l'envahissement médullaire par les blastes cytopénies voire pancytopénie, s'accompagnant parfois d'un passage des blastes dans la circulation sanguine.

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