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와파린은 초기에 ____________ 로 개발되었다. 설치류는 장내 세균을 통해 vitamin K를 대량으로 생산하여 와파린에 대한 저항성을 얻고 있기 때문에 ____________라 불리는 소수성 기를 도입하여 작용시간을 늘린 2세대 쿠마린 유도체들이 합성되었다.

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