The phosphoinositide-3 kinase (PI-3K) pathway is activated by insulin signaling in liver cells. Number the following statements 1-10 to order the sequence of events to insulin signaling.a. PDK1 and Akt bind to PIP3 in the plasma membrane via Ph domains.b. Insulin receptor autophosphorylates tyrosine residues in the cytoplasmic tail.c. Increased rates of glucose uptake and glycogen synthesis lower blood glucose.d. Insulin receptor phosphorylates IRS proteins on tyrosine residues. e. PI-3K phosphorylates PIP2 to generate PIP3.f. Insulin binds to the insulin receptor and activates its intrinsic kinase activity.g. IRS proteins bind to phosphotyrosine in the insulin receptor vis PTB domains.h. Akt is phosphorylated and activated by the serine/threonine kinase activity of PDK1.i. PI-3K binds the phosphotyrosine on IRK=S proteins via SH2 domains.j. Akt dissociates from PIP3 and phosphorylates downstream target proteins. (ch8)

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