The bacterium Vibrio cholera secretes cholera toxin that binds to the Gα subunit of the G Protein Coupled Receptor (GPCR), a type of metabotropic receptor. This will initiate the "mlc'lar switch" to lock Gα into its active conformation. As a result, downstream signaling cascades are hyperactive leading to excessive cAMP production & CTFR (calcium ion channel) stimulation which permits the flow of Cl- & H2O out of the cell. As a result, individuals who contract Vibrio cholera suffer from watery diarrhea. Based on your knowledge of metabotropic receptors, channel receptors, & osmosis, postulate a therapeutic intervention that would eliminate symptoms of a Vibrio cholera infection.

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