Scientists investigated the use of induced pluripotent stem cells (iPS cells) to treat type Idiabetes in mice. The scientists used four transcription factors to reprogramme skin cells toform iPS cells. The scientists then stimulated the in vitro differentiation of iPS cells intopancreatic cells.The scientists set up three experimental groups:• Group A - 30 mice with type I diabetes received pancreatic cell transplants derivedfrom iPS cells.• Group B - 30 mice with type I diabetes were left untreated.• Group C - 30 mice without diabetes were left untreated.The scientists measured the blood glucose concentration of all the mice on a weekly basisfor 12 weeks.The results the scientists obtained are shown in the graph.Suggest how transcription factors can reprogramme cells to form iPS cells.

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