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Renal Glomerular filtration : change in diurèses volume : drugs that decrease blood flow , decrease the filtration and thus affect the clearance of other drugs producing a decreased clearance .Tubular secretion : competition for active tubular secretion Tubular reabsorption : urinary pH changes can alter the degree of ionisation of drugs Urine alkalinization favours the elimination of acidic drugs . Example : phenobarbital

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