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Polyubiquitination is: A. The linkage of a ubiquitin moiety to multiple lysine residues on the target protein. B. The linkage of ubiquitin chains formed at specific lysine residues on ubiquitin to one or sites on the protein substrate. C. The linkage of randomly connected ubiquitin moieties to the substrate protein. D. The association of polyubiquitin chains to target proteins.

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