- Pili and filamentous hemagglutinin (FHA) - adhesion to ciliated epithelial cells, tracheal colonisation- Pertussis toxin (PTX; a classic A-B structure toxin) - inactivation host cell G proteins, activation of cAMP → increased secretion of upper respiratory tract epithelium- Adenylate cyclase toxin (ACT) - evasion by inhibiting phagocytosis- Dermonecrotic toxin (DNT) - peripheral vascular lesions with haemorrhage- Hemolysins - lysis of red blood cells- Tracheal cytotoxin - ciliostasis, promoted death of ciliated epithelial cells- Lipooligosaccharide (LOS) - damage to the epithelial cells of the upper respiratory tract, feverCapsule - evasion by inhibiting phagocytosis- 3 stages:1. Catarrhal stage - indistinguishable from the common cold, highly infectious2. Paroxysmal stage - loud inspiratory whoop, posttusive vomiting, cyanosis (bluish discolouration of the skin and mucous membranes)3. Convalescent stage - slow, chronic cough, which may last for weeks, gradual recovery

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