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Parakrin/autokrin: lokal kontroll. Viktig under benremodellering och läkning. Extracellulära benmatrix innehåller stora mängder tilläxtfaktorer producerade av osteoblaster som verkar mot andra osteoblaster.- Tillväxt - /signalfaktorer: (produceras av benceller och inflammationsceller) IGF, TGF-B, FGFs och BMB.- Andra lokala faktorer som producerats av benrelaterade celler (osteoblaster, inflammationsceller, makrofager): cytokiner, interleukiner och prostaglandiner
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