Oxidation of lactate to pyruvate inhibited, leading to reduction of gluconeogenesis and accumulation of lactate- Hypoglycemia result from the reduction in gluconeogenesis- The increased levels of acetyl-CoA-> fatty acid synthesis, excess NADH+ promotes the synthesis of glycerol for fat synthesis- TCA cycle reduce because they depend on NAD+- lactate in high concentrations promotes excretion of uric acid-> disease gout- High levels of lactate (acidosis) and acetyl-CoA (ketosis) lead to ketoacidosis

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