Mitochondria continually generate ROS, which can be damaging to cells with high rates of aerobic respiration. Put the following steps in the correct order to explain how ROS generated by mitochondria are neutralized by glutathione. Assume that NADPH levels need to first be maintained at a high level by the pentose phosphate pathway before ROS can be reduced. Removal of hydrogen peroxide is the final step. See Figure 14.9.Hydrogen peroxide is converted to water by the enzyme glutathione peroxidase in a reaction requiring reduced glutathione.G6PD reduces NADP+ to generate NADPH.Q cycle intermediate aberrantly donates e- to O2Oxidized glutathione is reduced by glutathione reductase in a reaction requiring NADPH.A superoxide radical combines with 2 H+ and e- to generate hydrogen peroxide.

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