​ Metatropic receptor signaling requires reception, transduction, and response; the addition of the transduction step could slow the process a bit. The responses can be relatively quick by way of modifying existing protein behavior, but it also requires the lengthy process of de novo gene expression to complete most responses. The Ionotropic receptor signaling is very rapid as ions are able to move across the membrane immediately upon receptor stimulation. The ion flow generates an immediate response. Nuclear receptor signaling may seem faster than metabotropic at first because it only uses reception and response steps. However, nuclear signaling accomplishes its response primarily through de novo gene expression, which is a lengthy process.

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