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Matrice de substitution ou de similarité:-Basée sur les __________ des AA(non polaire, chargé négativement ou positivement, polaires non chargés...)*-Conséquences si différences dans les séquences AA: -Substitution d'un AA par un autre de nature très __________ - Substitution d'un AA par un autre de nature __________(susceptible de conserver la structure et la fonction de la protéine)-Fournissent un score de ___________ entre 2 AA*

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