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Lunge, Chron. Lungenemphysem, Van Gieson Beschreibung:unterschiedl . große luftgefüllte Hohlräume ; zerstörte Alveolarwände ( teils fibrosiert oder entzündl . verändert ) ; erweiterte Alveolarlichtung ; Abnahme elast . Fasern ; Zunahme kollagener Fasern ; Anthrakose ( Staubpartikel in Makrophagen )Allg:abnorme , anhaltende Erweiterung des resp . Anteils der Lunge; distal des Lungenazinus ; Formen : Altersemphysem, panazinär , zentroazinär ; ungehemmte Akt . von Proteasen und Elastase-> proteolyt . Zerstörung Alveolarwände ; Bulla ( große Luftblasen ) subpleural → Spontanpneu . bei Ruptur
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