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Les proto-oncogènes activés en oncogènes subissent des mutations à effet dominant. C'est-à-dire qu'il suffit qu'un seul des 2 protooncogènes parentaux soit muté en oncogène (une seule des 2 copies du gène soit mutée) pour produire suffisamment de protéines anormales pour stimuler la division cellulaire de manière permanente. Ce sont des mutations de type « gain de fonction » (mutations des gènes codant les cyclines/CDK sont des surexpressions/gain de fct)

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