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- Insuffisances hépatiques et rénales- Hyperlipidémie- Hypervitaminose A- Patients déprimés (risque de suicide)- Allaitement et grossesse (TERATOGENE)- TétracyclinesNB : Protocole particulier de prescription et de dispensation de l’Isotrétinoïne (per os)NB : Les rétinoïdes par voie locale peuvent avoir les mêmes effets tératogènes que lorsqu'ils sont administrés par voie orale pendant la grossesse

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