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How does a cell know which sequences to remove from the pre-mRNA transcript as introns? Complementary sequences in the snRNP bind to the splice sites in the primary transcript.Introns possess physical distortions that spliceosomes recognize and bind to. Introns have modified bases that are recognizable from the normal, A, G, C, and U. Protein kinases recognize phosphorylated regions near the splice sites. It's magic!
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