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- Hepatocytes lack basement membrane ⇒ Direct contact with circulating substances→ The blood from portal vein arrives to the liver and spreads.- 15% cells are macrophages ⇒ Kupffer cells- High regeneration capacity (up to 75%)- Medium poor in oxygen ⇒ 75% of the blood goes to the portal vein, which is deoxygenated.- High metabolic transformation

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