- Heme is a constituent of hemoglobin, myoglobin, and cytochromes - Heme is synthesized in most cells of the body- The liver is the main nonerythrocyte source of its synthesis- Heme is a porphyrin, a cyclic compound that contains four pyrrole rings linked together by methenyl bridges- It is synthesized from glycine and succinyl-coenzyme A, which condense to form 5-aminolevulinate (5-ALA)- This reaction is catalyzed by 5-ALA synthase, located in mitochondria, and is rate limiting in heme synthesis

Then try StudyFetch, the AI-powered platform that can answer your questions and teach you more about it!