HCC risk factors:- _____ of almost any cause: inflammation, necrosis, fibrosis, and cirrhotic liver can contribute to HCC- _____ infection: viral load (high serum levels of HBV DNA --> greater risk), active viral replication (HBeAg positivity)- _____ infection: in the setting of chronic inflammatory state induced by the virus- _____: free iron --> rapid formation of ROS metabolites --> DNA damage, abnormal protein synthesis and cell proliferation --> cell injury and fibrosis

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