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- hépatocytes : seuls capable de dégrader la structure tétracyclique du cholestérol- le foie :seul organe capable de le solubiliser + l'éliminer sous la forme d'acide biliaire excrétée dns la bile-plusieurs transformation du cholestérol : réduction de la taille de la chaîne latérale apparition d'1 fc acideces modification augmentent la solubilité

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