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Glucose-6-phosphate déshydrogénaseo Oxydation du G6P en 6-phosphogluconate Oxydation de la fonction aldéhyde en C1 pour former un acide carboxylique Formation d'un intermédiaire : 6-phospho-glucono-δ-lactone Hydrolyse de lactoneo Production d'1 NADPH, H+ Réduction : transfert des électrons sur le NADP+- Réaction limitante et régulatriceo Seule étape du segment oxydatif régulée par le NADP+ NADP+ = activateur allostérique de la glucose-6-phosphate déshydrogénase

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