Glucocorticoids regulate a variety of cell-specific physiologic responses, ranging from anti-inflammatory action in immune cells to stimulation of carbohydrate synthesis in liver cells. Given the following three observations, what explains the cell specificity of glucocorticoid signaling? (1) Glucocorticoid receptors are expressed in essentially all human call types. (2) Glucocorticoid hormones are endocrine signaling molecules that are circulated throughout the entire body. (3) The DNA sequence in every cell is 99.99% identical. (ch8)

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