Given what we learned in the class about ubiquitination, which of the following statements is correct? A. The ubiquitin system is essential for cell viability (i.e. knockout mice lacking the E1 or some E2 enzymes will be embryonic lethal). B. Disruption of ubiquitination will not interfere with cell physiology. C. The ubiquitin system plays no role in our defense against infection. D. Ubiquitin molecules in the cells is always made fresh by the transcription-translation starting from the DNA sequences coding for ubiquitin.

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