Given a deficiency in tetrahydrobiopterin, how might one go about calculating the kinetics of phenylalanine hydroxylase using the Michaelis-Menten equation?(Choice A)No modifications would be needed as there is no term in the Michaelis-Menten equation corresponding to cofactor concentration.Choice B, Since cofactors are also substrates, the term representing substrate concentration could be used to account for cofactor concentration.(Choice C)The effects of the substrate would be incorporated into the Kcat value.(Choice D This reaction would exhibit non-Michaelis-Menten kinetics, so the Michaelis-Menten equation could not be used in this case as it stands.

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