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Giả thuyết nguyên nhân: ...dựa trên 2 chứng cứ: Thuốc điều trị tăng huyết áp reserpine: ức chế vận chuyển monoamin, gây trầm cảm ở một số bệnh nhân. Thuốc chống trầm cảm ức chế enzyme oxy hóa monoamin (MAOI), thuốc chống trầm cảm 3 vòng (TCA) có cơ chế giống nhau là tăng nồng độ monoamin tại khe synapse.
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