Fetal hemoglobin comprises of αγ sub-units. It has been found that the γ-chain contains serine at position 143 instead of Histidine 143 normally found in the β-chain. The amino acid 143 lines the DPG binding site. This mutation in the γ chain results ina) Increased Oxygen binding in the fetus.b) This is a silent mutation, i.e. no change should be observed.c) Increased DPG binding in the fetal hemoglobind) Increased efficiency of oxygen transport to the lungs in the fetus.

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