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Eukaryotic cells store their DNA in the form of linear chromosomes. This creates problems for replication of DNA at the ends of the chromosomes because DNA polymerase cannot access the nucleus, where the DNA is found. by the time DNA polymerase gets to the ends, there are no more free dNTPs for replication. all of the genes are located in the middle of the chromosomes. base pairs at the ends of chromosomes do not consist of A, C, G, or T. DNA polymerase can only synthesize DNA in the 5' to 3' direction.
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