EGF-R patho Discuss how the EGF-R becomes activeo How does the active receptor recruit substrate, and how does substrate hold ontoreceptor? When held, what "options" in regards to what the receptor does tobound substrate?o What proteins are involved in the recruitment of ras to the receptor, and how doesras become active - what does it do then? Make sure you include the G-proteinstory.o When active, ras triggers the MAPK cascade - what is the end result of this path.o Discuss the most common mutation in the ras gene found in cancer cells - how does this mutation play a role in the cancer cell story?

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