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CLL pathogenesis:- Indolent, _____ growing tumor --> Increased tumor cell survival appears to be more important than tumor cell proliferation- 50% of tumors have _____ abnormalities --> Most common are trisomy 12 and deletions involving portions of chromosomes 11, 13, and 17 --> Negative regulators of anti-apoptotic _____ (overexpression --> tumor survives longer)- Chromosomal translocations are _____ in CLL
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