BPH pathophysiology:- Type 2 _____-_____-_____- enzyme that forms _____ in the prostate from testosterone- DHT binds to the nuclear AR present in both stromal and prostate epithelial cells --> Stimulates transcription of androgen-dependent genes fibroblast GF (FGFs) family and transforming growth factor (TGF-beta) - FGFs produce _____ _____ in BPH - TGF-beta serves as a mitogen for fibroblasts and other mesenchymal cells, but inhibits epithelial apoptosis DHT-induced growth factors act by increasing the proliferation of _____ cells and decreasing the death of _____ cells

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