- Botulotoxin, by its structure and functions, is similar to tetanospasmin!!- Botulotoxino Light (A) chain - responsible for neurotoxicityo One or more heavy (B) chains - responsible for attachment to the cell and ensuring exotoxin molecule stability in the acid environment of the stomach- Botulotoxin is specific against cholinergic nerves ® flaccid paralysisTheir role in the pathogenesis of infections:- soil and water samples- Four forms:1. classic or foodborne botulism - home-made canned foods2. infant botulism - food with C. botulinum spores uptaken by infant3. wound botulism - the incidence is unknown, and the disease is very rare4. inhalation botulism-botulinum toxin has been concentrated for aerosolisation as a biological weapon. When administered in this manner, inhalation disease has a rapid onset and potentially high mortality

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