- Bilirubin is the catabolic product of heme- About 75% of all bilirubin is derived from the breakdown of hemoglobin from senescent red blood cells, which are phagocytosed by mononuclear cells of the spleen, bone marrow, and liver (reticulo-endothelial cells)- In normal adults, the daily load of bilirubin is 250-350 mg- The ring structure of heme is oxidatively cleaved to biliverdin by heme oxygenase, a P-450 cytochrome- Biliverdin is, in turn, enzymatically reduced to bilirubin

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