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Are used to treat all anxiety disorders except obsessive compulsive disorder. SNRIs work by preventing the reuptake of 5-HT and NE by synapses in the brain. Compared with venlafaxine and desvenlafaxine, which have SRI activity and dose-related affinity for norepinephrine reuptake inhibition (NRI) primarily, duloxetine has more balanced SRI and NRI activities. Levomilnacipran has higher activity at NRI than SRI.
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