抗生素濃度相關:Aminoglycoside耳毒、Fluoroquinolone、Metronidazole時間相關:β-lactam、Glycopeptide(萬古黴素)、Clindamycin抗生素配對原則:殺菌配殺菌(心內膜炎),抑菌配抑菌。腎毒:萬古黴素、Cosplatin、Amophtericin、Methoxyflurane、Cyclosporine A、Aminoglycoside1.)抑制細胞壁、膜一殺菌(Ex.Penicillin,Cephalosporins、Monobactams、Carbapenems、Vancomyin、Bacitracin)2.)影響蛋白質一抑菌(Ex.四環黴素(-cycline)、Macrolide巨環類 (-thromycin)、Chloramphenicol氯黴素、Lincosamide林克醯胺) 殺菌(Ex.Aminoglycosides)3.)影響核酸一抑菌(Ex.Sulfonamide) 殺菌(Ex.Metronidazole、Quinolone、Rifampin)所以Chloramphenicol(抑菌)+Piperacillin(菌)一拮抗作用。蛋白質合成抑制(30S): 四環黴素(-cycline)、AMG(可逆/mRNA錯誤解讀)蛋白質合成抑制(50S): Macrolide巨環類 (可逆)(-thromycin)、氯黴素、Lincosamide林克醯胺(可逆)、Streptogramin鏈"陽"黴素Linezolid: 結合"50S"的"23S"、抑制"70S"起始複合物協同β-lactam+AMG: 更易進入Amphoterin B+Flucytocine: 更易進入鏈黴素+Penicillin: 心內膜炎

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