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Amide type; very common, usually premixed with epinephrine, can be buffered with bicarb- used in infiltration, peripheral nerve block, epidural, spinal and topical anesthesia- moderate hydrophobicity (therefore moderate potency)- doses for blocks are lower than infiltration (due to compartment syndrome)- rapid onset (2-5 minutes), medium duration of action (30-60 minutes)- also used as class I anti-arrhythmic; blocks NA channels in myocytes

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