A 60-year-old man comes to the physician because of recurrent nose bleeds that occur with light trauma or at random times during the day. Over the past 6 months, the patient has felt weak and fatigued and has had a 10-kg (22-lb) weight loss. He has poor appetite and describes abdominal discomfort. He does not have night sweats. His pulse is 72/min, blood pressure is 130/70 mm Hg, and his temperature is 37.5°C (99.5°F). The spleen is palpated 10 cm below the left costal margin. Multiple bruises are noted on both upper extremities. Laboratory studies show.Hemoglobin 9.8 g/dLHematocrit 29.9%Leukocyte count 4,500/mm3Neutrophils 30%Platelet count 74,000/mm3Serum Lactate dehydrogenase 410 IU/LA peripheral blood smear detects tartrate-resistant acid phosphatase activity. Which of the following is the most appropriate initial treatment for this patient?

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