A 28 year old woman is scheduled for an elective cholecystectomy. She has a history of recurrent epistaxis(nosebleed) and menorrhagia(period 7days+). She recalls her mother having a hysterectomy for menorrhagia. Clinical examination is normal Investigations preoperative Haemoglobin 98 g/L (115-150) Platelets 160 x 10°/L (150-400) White cell count 6.7 x 10/38-100) PT 11 seconds (10-12) APTT 82 seconds (22-41) Thrombin time 13 seconds (9-15) Which is the most likely explanation for these results?

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