A 27 year old woman is admitted with increasing cough and wheeze. She has asthma.Her pulse is 120 bpm, blood pressure 118/78 mmHg, respiratory rate 30 breaths per minute and oxygen saturation 97% breathing high flow oxygen. She has widespread expiratory wheeze.She has received nebulised salbutamol and remains breathless.What additional treatment will be most effective in causing relaxation of airway smooth muscle?Beta-1 adrenoceptor agonistBeta-2 adrenoceptor antagonistMuscarinic receptor antagonistPhosphodiestarase inhibitorLeukotriene receptor antagonist

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