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7. (7 points) Red blood cells synthesize and degrade 2,3-bisphosphoglycerate (BPG) as a detour from the glycolytic pathway (as shown below). BPG decreases the oxygen affinity of hemoglobin by binding in the central cavity of the deoxygenated form of hemoglobin. This encourages delivery of oxygen to tissues. A defect in one of the glycolytic enzymes may affect levels of BPG. The plot shows oxygen-binding curves for normal erythrocytes and for hexokinase-deficient and pyruvate kinase-deficient erythrocytes. Identify which curve corresponds to which enzyme deficiency. Justify.
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