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この島には15,000人の人々が住んでいた[ヒスパニョーラ島、1508年]、そのため1494年から1508年までに、300万人以上の人々が戦争、奴隷労働、鉱山で亡くなりました。将来の世代の誰がこれを信じるでしょうか？ - バルトロメ・デ・ラス・カサス神父、インディアスの歴史、1561年（*おそらく大幅に過大評価された可能性がありますが、重要な点です）生物兵器の直接的なインスタンス？1492年：カリブ海へのヨーロッパ人の到着疫病が直ちに始まり、天然痘、はしか、インフルエンザ、結核、百日咳が含まれています。しかし、天然痘は遥かに最も大きな影響を与えたようです。影響はおそらく人類史上最大の人口統計的および文化的災害でしたおそらく4000万〜9000万人の死亡（数世紀にわ
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