10.39 A research team interested in social behavior has been studying different populations of laboratory rats. By using a selective breeding strategy, they have developed two populations of rats that differ markedly in their behavior: one population is abnormally calm and placid, while the second population is hyperactive, nervous, andeasily startled. Biochemical analyses of brains from eachpopulation reveal different levels of a catecholamine neurotransmitter,a molecule used by neurons to communicate with each other. Relative to normal rats, the hyperactive population has increased levels while the calmpopulation has decreased levels. Based on these results, the researchers have hypothesized that the behavioral and biochemical differences in the two populations are caused by variations in a gene that encodes an enzyme used in the synthesis of the catecholamine. Suppose youhave a set of SNPs that are distributed throughout the rat genomic region containing this gene, including its promoter,coding region, enhancers, and silencers. How could you use these SNPs to test this hypothesis?

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