1.) immune cells exposed to a allergen 2.) APC takes up allergen and processes it on class II MHC to present to a CD4 T cell 3.) activation of a Th2/Tfh cells which secrete IL-4/IL-13 4.) IL-4 and IL-13 stimulate B cells to class switch to IgE producing plasma cells 5.) plasma cells secrete IgE 6.) IgE antibodies bind to high affinitiy Fc receptor on mast cells/basophils 7.) future exposure to the allergen causes cross-linking of IgE on the mast cell/basophil which activates the mast cell/basophil

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