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1. GI symptoms: upset stomach and epigastric pain2. avoid use in renal impairment and heart failure3. GI ulceration, perforation, bleeding: risk factors are previous ulcer disease, using anticoagulants, high dose, long duration, >3 alcohol per day4. increased risk of myocardial infarction (MI), heart failure, hypertension, stroke - worse with high doses and long duration - cardiovascular disease avoid NSAIDs
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