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1)Careful anamnesis 2)Avoid polymedication 3)Frequently check treatment 4)Don't make excessive treatment changes 5)Special care with : cytostatique drugs , Hypoglycaemic drugs,Psychotropic drug, Cardiovascular drugs, Theophylline6)alterations of laboratory tests 7) a drug can be involved in many interactions 8) unexpected event during treatment —> suspect interaction

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