Intracellular accumulation 4 pathways:1. Abnormal _____: results in accumulation of a normal substance (fatty liver hypercholesterolemia)2. _____: cause alterations in protein folding and transport defective molecules accumulate intracellularly (cystic fibrosis, Alzheimer's, prion's disease)3. Deficiency of _____: responsible for breaking down certain compounds, causing substrates to accumulate in lysosomes, as in lysosomal storage diseases (glycogen-storage diseases, lipid-storage diseases)4. Inability to _____: phagocytized particles, as in carbon pigment accumulation (pneumoconiosis, asbestosis, silicosis)

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