The endocrine system consists of a number of ductless glands that secrete hormones directly into the blood. Examples include the pancreas, adrenal glands, thyroid gland, and pituitary gland.Hormones are chemical messengers (proteins or steroids) transported around the body in the bloodstream. Hormones cause a change in activity of target cells.Homeostasis is the maintenance of the internal environment. Certain factors (such as blood glucose levels and temperature) must remain within certain limits. If changes occur, mechanisms act to bring these factors back to within original limits (this is called negative feedback).

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